Methylene Blue Intake Form Template

Methylene Blue is a phenothiazine compound with mitochondrial-targeting and monoamine oxidase inhibitory properties. It is prescribed off-label through compounding pharmacies for cognitive enhancement, mitochondrial dysfunction, chronic fatigue, and mood support. Due to its MAO inhibitory activity, Methylene Blue carries a serious risk of serotonin syndrome when combined with serotonergic medications. Thorough medication screening is critical before prescribing.

5 sections
20 fields
HIPAA-ready
3 citations

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Methylene Blue Intake Form

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Your Practice Name

Methylene Blue Intake Form

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1

General Patient Information

Please provide your personal information.

First Name

Jane

Last Name

Smith

Date of Birth

Can you confirm you are 18 years or older?

Height

e.g. 5'8"

Weight

e.g. 170 lbs

2

Medical History

Please answer all questions as accurately as possible. Your provider will review this information.

Are you actively taking any medications? If so, please list them.

List all current medications, dosages, and frequencies

Do you have any medication allergies? If so, please list them.

List all known drug allergies and reactions

Are you currently being treated or have you been treated for any medical conditions? If so, please list them.

List all current and past medical conditions

Have you had any past surgeries? If so, please list them.

List all surgeries and approximate dates

What is/was your sex assigned at birth?

Male

Emergency contact name and phone number

Name — (555) 000-0000

Mailing address

123 Main St, City, State, ZIP

Any other questions or concerns?

Optional — share anything else you'd like your provider to know

3

Symptoms

Select all symptoms that currently apply to you.

Which of the following symptoms are you experiencing?
4

Contraindications

Please read each item carefully and select all that apply.

Do any of the following apply to you?
5

Additional Screening Questions

These questions are required for safe Methylene Blue prescribing.

Do you have a known deficiency of G6PD (glucose-6-phosphate dehydrogenase)?

Are you currently taking any of the following medications?

Do you understand that you should not consume alcohol while taking Methylene Blue, as it may increase the risk of liver damage and affect how your body metabolizes ethanol?

Yes
No

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Compliance & Regulatory Notes

Review these notes before deploying this form in your practice.

Methylene Blue has MAO inhibitory activity and carries an FDA boxed warning for serotonin toxicity when combined with serotonergic agents. This is a critical drug interaction that must be screened before every prescription. See FDA Drug Safety Communication: https://www.fda.gov/drugs/drug-safety-and-availability

G6PD deficiency is a contraindication. Methylene Blue relies on G6PD for its reduction and can cause hemolytic anemia in G6PD-deficient patients.

Methylene Blue for clinical use must be compounded or sourced as a pharmaceutical-grade product. Avoid research-grade sources. See FDA: https://www.fda.gov/drugs/human-drug-compounding

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Sources & References

  1. FDA Drug Safety Communication - Methylene Blue and Serotonin Toxicity
  2. FDA Human Drug Compounding Guidance
  3. FSMB Off-Label Prescribing Guidelines

Frequently Asked Questions

Why is serotonin syndrome a concern with Methylene Blue?

Methylene Blue inhibits monoamine oxidase (MAO), which metabolizes serotonin. When combined with SSRIs, SNRIs, MAOIs, or other serotonergic drugs, this can cause dangerous serotonin accumulation leading to serotonin syndrome, a potentially life-threatening condition.

What is G6PD deficiency and why does it matter?

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic condition affecting red blood cell antioxidant defense. Methylene Blue requires G6PD activity to function as an antioxidant and can cause hemolytic anemia in G6PD-deficient patients.