OpenLoop vs Karpa: Telehealth Platform Comparison (2026)
OpenLoop vs Karpa: compare physician model, pharmacy integration, and program depth for peptide and GLP-1 telehealth clinics.
Last reviewed: October 15, 2026
TL;DR
OpenLoop publicly offers white-label telehealth with its own clinician network, pharmacy and lab fulfillment, and a broad program catalog, with pricing by quote. Karpa focuses on peptide, GLP-1, TRT, and HRT programs and uses its 50-state network of independent licensed providers for every prescription.
Karpa Health
- Starting price
- $297/mo
- plus a one-time implementation fee
- Time to launch
- 7–30 days
- about 7 with your own website and LegitScript certification; about 30 when Karpa builds the website
OpenLoop
- Starting price
- Not publicly listed
- Time to launch
- As little as a day on its Launchpad platform
About OpenLoop
- Founded
- January 2020, Des Moines, Iowa (co-founders Dr. Jon Lensing and Christian Williams)
- Funding
- Venture-backed; $8M Series A (March 2022, led by SpringTide Ventures) and $15M Series A (March 2023, led by Nava Ventures)
At-a-Glance Comparison
Side-by-side comparison across features, pricing, and business model.
Karpa wrote this comparison and is one of the two platforms compared. Every competitor fact comes from a public source cited at the end of the page, reviewed October 15, 2026. “Not publicly specified” means we could not verify that detail from a public source.
Spot something wrong or out of date? Contact us with a public source, and we’ll review it and update the page.
| FEATURE | Karpa Health | OpenLoop |
|---|---|---|
| PLATFORM DETAILS | ||
| Platform Type | Turnkey program launcher | White-label telehealth infrastructure (clinicians, technology, pharmacy, and billing) Source |
| Best For | Individual practices adding peptide, GLP-1, TRT, or HRT programs, and entrepreneurs launching 50-state telehealth brands | Organizations that want to offer virtual care under their own brand without hiring clinicians, from first-time operators to clinics, medspas, gyms, and health systems Source |
| Physician Model | Karpa's 50-state network of independent licensed providers prescribes for every program, sync and async | OpenLoop-provided nationwide clinician network; the site states 50-state coverage and thousands of licensed clinicians Source |
| Peptide Support | Primary focus with dedicated workflows | Listed program; OpenLoop states it offers only Category 1 peptides approved for 503A compounding; longevity program names NAD+, sermorelin, and B-12 Source |
| GLP-1 Support | Primary focus with dedicated workflows | Medical Weight Loss program with branded and compounded GLP-1s, plus GLP-1 microdosing; compounded availability varies by state Source |
| Pharmacy Integration | Direct integration with our compounding pharmacy partners | Nationwide pharmacy and lab network including 503A compounding pharmacies and 503B outsourcing facilities; built-in e-prescribing and fulfillment Source |
| Pricing | Launch plan $297/mo plus a one-time implementation fee (custom website, patient portal, signup forms); Growth and Scale shared on a call; custom EMR quote | Not publicly listed; OpenLoop states pricing varies based on the services added and directs buyers to sales Source |
| BUSINESS MODEL | ||
| White-Label Branding | Source | |
| Pass-Through Pricing | — Source | |
| Patient Ownership | ? | |
| You Are Merchant of Record | — Source | |
| Bring Your Own Pharmacy | — | ? |
| LegitScript Certified | Source | |
OpenLoop: What You Should Know
OpenLoop is a close comparison for operators who want a branded telehealth program with clinicians, pharmacy, and technology supplied by one vendor. Its public materials describe 50-state clinician coverage, a broad program catalog, and an insurance payer network in addition to cash-pay programs. Karpa focuses on peptide, GLP-1, TRT, and HRT programs and uses its 50-state network of independent licensed providers to prescribe.
OpenLoop's site lists payment processing as part of the platform and advises partners to confirm branding, data-use, and transition terms in their agreement. OpenLoop's terms of use state that OpenLoop charges patients, so it, not the partner, is the merchant of record. Buyers should confirm pricing, patient data ownership, pharmacy options, and whether their own prescribers can be used.
OpenLoop: Strengths & Limitations
Strengths
- Broad program catalog beyond weight loss, including peptides, hormone therapy, dermatology, diagnostics, sleep testing, and behavioral health
- OpenLoop supplies the clinician network, stated as 50-state coverage, so operators do not recruit or credential clinicians
- Pharmacy and lab network that includes 503A compounding pharmacies and 503B outsourcing facilities
- Single platform covering intake, portal, EHR, payment processing, video, and patient communications
- Stated payer network of 600+ insurance plans, including Medicare and Medicaid
- States it holds LegitScript Healthcare Merchant Certification (announced April 2023)
- Provider staffing services for organizations with their own clinical infrastructure
Limitations
- Pricing and contract terms are not publicly specified
- OpenLoop is the merchant of record: its terms of use say OpenLoop (or its payment processor, Stripe) charges the patient's payment method; patient data ownership is not publicly specified
- Whether partners can prescribe through their own clinicians on the platform is not publicly specified
- Compounded GLP-1 availability varies by state, per OpenLoop
OpenLoop or Karpa: Who Each Is Best For
Who OpenLoop is best for
OpenLoop is a strong choice for organizations that want to offer virtual care under their own brand without hiring clinicians, from first-time operators to clinics, medspas, gyms, and health systems.
OpenLoop is a Des Moines, Iowa white-label telehealth infrastructure company. It describes itself as providing clinicians, technology, pharmacy, and billing across all 50 states, with patient-facing surfaces built under the client's brand. Its listed programs include peptides, GLP-1 weight loss, hormone therapy, sexual health, dermatology, diagnostics, sleep apnea testing, dietitians, and behavioral health. Its Launchpad platform bundles intake, patient portal, EHR, payment processing, and AI support. In 2026 it acquired Season Health (registered dietitians) and Hey Revia (AI patient communications).
Who Karpa Health is best for
Entrepreneurs, clinicians, and operators who want to launch a real telehealth business, not rent someone else's. Whether you're a licensed clinician adding cash-pay programs or a non-medical founder launching a 50-state brand, Karpa gives you full control.
- Pass-through pricing on pharmacy and provider fees
- You are merchant of record and get paid first
- Full white-label branding, patients only see your brand
- You fully own the patient relationship
- No medical license required, use Karpa's 50-state network of independent licensed providers
Operators already running on Karpa have left reviews on G2 and Capterra. Read the Karpa Health reviews, quoted word for word with the reviewer, the date and a link to each source.
Explore Karpa's Programs
You are deciding between OpenLoop and Karpa. The next step is seeing how a Karpa program runs under your own brand.
Switching from OpenLoop
Operators comparing a transition should confirm data portability, patient communication terms, clinical responsibilities, pharmacy options, and commercial terms directly with both vendors.
- 01
Initial Consultation
Book a gameplan session to map your current workflows to Karpa's platform.
- 02
Platform Setup
Karpa configures intake forms, protocols, pharmacy connections, and your branding.
- 03
Go Live
Live in about 7 days with your own website and LegitScript certification, with one-click pharmacy fulfillment.
Frequently Asked Questions
How much does OpenLoop cost?
OpenLoop pricing, as of October 15, 2026: Not publicly listed; OpenLoop states pricing varies based on the services added and directs buyers to sales. For comparison, Karpa Health publishes its starting price: the Launch plan is $297/mo plus a one-time implementation fee, month to month.
OpenLoop reviews: what are the pros and cons?
This is Karpa Health's review of OpenLoop, based on OpenLoop's own public materials as of October 15, 2026. Karpa competes with OpenLoop, so weigh it accordingly. Pros: Broad program catalog beyond weight loss, including peptides, hormone therapy, dermatology, diagnostics, sleep testing, and behavioral health; OpenLoop supplies the clinician network, stated as 50-state coverage, so operators do not recruit or credential clinicians. Cons: Pricing and contract terms are not publicly specified; OpenLoop is the merchant of record: its terms of use say OpenLoop (or its payment processor, Stripe) charges the patient's payment method; patient data ownership is not publicly specified. The full list, with a source for each fact, is on this page.
Can I switch from OpenLoop to Karpa Health?
Yes. Karpa's onboarding team migrates your patient records, active prescriptions, and refill schedules, so current patients keep their refills without starting over; continuing prescriptions are reviewed by independent licensed providers in Karpa's network. We rebuild your intake, checkout, and patient portal under your brand, connect pharmacy fulfillment, and handle LegitScript through our Enterprise Certification Partner status (review within 2 business days). If you already have your own website and LegitScript certification, you can go live in about 7 days. Start by requesting an export of your patient list from OpenLoop. Operators comparing a transition should confirm data portability, patient communication terms, clinical responsibilities, pharmacy options, and commercial terms directly with both vendors.
Does Karpa Health support organizations that want to offer virtual care under their own brand without hiring clinicians, from first-time operators to clinics, medspas, gyms, and health systems?
Karpa Health is purpose-built for entrepreneurs and clinicians launching cash-pay GLP-1, peptide, TRT, and HRT programs. You don't need a medical license to launch. If your primary need is organizations that want to offer virtual care under their own brand without hiring clinicians, from first-time operators to clinics, medspas, gyms, and health systems, OpenLoop may fit. If you want to own the patient, set your own prices with pass-through pharmacy costs, and launch under your own brand, Karpa is the stronger choice.
What pharmacies does Karpa integrate with?
Karpa Health has direct integration with our compounding pharmacy partners for one-click prescribing. Prescriptions route to those partners automatically, so there is no pharmacy for you to bring or contract.
Do I need a medical license to use Karpa?
No. Independent licensed providers in Karpa's 50-state network prescribe, so non-medical entrepreneurs can launch without a license. You own the patient relationship, control the brand, and act as merchant of record.
How long does it take to launch a program with Karpa?
About 7 days if you already have your own website and LegitScript certification. If Karpa builds your website, plan on about 30 days: about 2 weeks for the site, then LegitScript approval, typically 14–21 days with Karpa (5 days at fastest). Karpa provides pre-built intake forms, clinical protocols, pharmacy connections, and patient communication templates.
References
- OpenLoop homepage and FAQ
- OpenLoop Launchpad
- OpenLoop Terms of Use, Section 10: Payment
- OpenLoop Clinician Network
- OpenLoop Pharmacy and Diagnostics
- OpenLoop Program Overview
- OpenLoop Medical Weight Loss
- OpenLoop AI and Operations
- OpenLoop for clinics and local businesses
- OpenLoop earns LegitScript certification (April 2023)
- OpenLoop raises $8M Series A (March 2022)
- OpenLoop raises $15M Series A (March 2023)
- This Is Iowa: OpenLoop founded January 2020
- OpenLoop Team
- OpenLoop H1 2026 recap
- HLTH: OpenLoop acquires Hey Revia
Ready to launch?
Launch your white-label GLP-1, peptide, or hormone therapy brand, live in about 7 days with your own website and LegitScript certification. Pass-through pricing, your brand, your patients.